Myeloid leukemia is a group of diseases whose characteristic changes are seen in the bone marrow and blood, where tumor cells infiltrate the blood system; sometimes these cells even spill in to the circulating blood other tissues. The idea of myeloid leukemia is from the action of immature white blood cells being produced in excess and therefore inhibiting the production of the normal blood cells. These cells are called myeloid cells; they by their action in the blood disturb the function of the blood cells.This leukemia has both tumors which are kept untreated to those that are diagnosed and treated immediately, ranging from speedy fatality to those which are slow in growing. Therefore on the basis of their treatment coursework they are divided in to acute myeloid leukemia (AML) and chronic myeloid leukemia (CML).AML is seen more in men than in females and more prevalent in people older than 65 than in people of more youthful age. CML is also greater in men than in females but its incidence always increase slowing and the people’s age increases and gets to the peak of occurrence in mid forties from where there is speedy rise in CML occurrence. Anyway the incidence of CML decreased slightly historically decades.The etiology of myeloid leukemia is depended on the type, AML is related with risk factors such as hereditary (other resident blood disease in the relatives history; DIC) exposure to occupational chemicals, intense exposure to radiation which may be because of therapeutic reasons and even some drugs, but there is nothing relating the reason for ML to viral infection in any way.
While the etiology of chronic myeloid leukemia has no distinct relation with cytotoxic drug effect and there is also no facts connecting it with any viral infection, but cigarette smoking by studies has shown to increase its progress in to extreme crisis, therefore living with Chronic myeloid leukemia and smoking becomes hazardous. Only large dosage of radiation has any adverse effect for CML formation.The signs of ML are also depending on the type, whether it is AML or CML. For AML patients are introduced with some nonspecific signs which start either slowly or abruptly and the signs are leucopenia or leucocytosis, thrombocytopenia. These signs are usually due to anemia in such patients. Other signs of are fatigue, anorexia and weight loss and basically getting bruised with excessive bleeding.While in CML the signs are at first insidious therefore it is difficult to diagnose a patient based but signs, such patients are usually diagnosed in the coursework of normal medical checkup, or others come to the hospital with complaints fatigue, weight loss, signs relating to splenomegaly such as early satisfaction in the coursework of eating, left upper quadrant pain, infections, thrombosis or sometimes bleeding.When chronic myeloid leukemia progresses signs worsened with bone and joint pain, significant loss of weight which will need increasing the dose of the drugs used for treatment. Chemotherapy is used as treatment of myeloid leukemia but when this fails bone transplant is completed.
